×
Entrez Id:
351
Gene Symbol:
APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Vitamin E protects nerve cells from amyloid beta protein toxicity.
1497677
1992
×
Entrez Id:
351
Gene Symbol:
APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
The BET-Bromodomain Inhibitor JQ1 Reduces Inflammation and Tau Phosphorylation at Ser396 in the Brain of the 3xTg Model of Alzheimer's Disease.
27117003
2016
×
Entrez Id:
351
Gene Symbol:
APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Synchrotron-based infrared and X-ray imaging shows focalized accumulation of Cu and Zn co-localized with beta-amyloid deposits in Alzheimer's disease.
16325427
2006
×
Entrez Id:
351
Gene Symbol:
APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Structural studies of the Alzheimer's amyloid precursor protein copper-binding domain reveal how it binds copper ions.
17239395
2007
×
Entrez Id:
351
Gene Symbol:
APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Solution 1H NMR investigation of Zn2+ and Cd2+ binding to amyloid-beta peptide (Abeta) of Alzheimer's disease.
16266835
2006
×
Entrez Id:
351
Gene Symbol:
APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Recombinants between the APP gene and the AD locus have been reported which seemed to exclude it as the site of the mutation causing familial AD .
1671712
1991
×
Entrez Id:
351
Gene Symbol:
APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Quantitative Genetics Validates Previous Genetic Variants and Identifies Novel Genetic Players Influencing Alzheimer's Disease Cerebrospinal Fluid Biomarkers.
30320580
2018
×
Entrez Id:
351
Gene Symbol:
APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Protective Effect of Notoginsenoside R1 on an APP/PS1 Mouse Model of Alzheimer's Disease by Up-Regulating Insulin Degrading Enzyme and Inhibiting Aβ Accumulation.
25714973
2015
×
Entrez Id:
351
Gene Symbol:
APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
pH-Dependent Cu(II) coordination to amyloid-β peptide: impact of sequence alterations, including the H6R and D7N familial mutations.
21980910
2011
×
Entrez Id:
351
Gene Symbol:
APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Peroxisomal proliferation protects from beta-amyloid neurodegeneration.
16204253
2005
×
Entrez Id:
351
Gene Symbol:
APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Oxidation of cholesterol by amyloid precursor protein and beta-amyloid peptide.
15591071
2005
×
Entrez Id:
351
Gene Symbol:
APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Oral administration of methysticin improves cognitive deficits in a mouse model of Alzheimer's disease.
28448946
2017
×
Entrez Id:
351
Gene Symbol:
APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
On the metal ion (Zn(2+), Cu(2+)) coordination with beta-amyloid peptide: DFT computational study.
20640797
2010
×
Entrez Id:
351
Gene Symbol:
APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Mis-sense mutation Val----Ile in exon 17 of amyloid precursor protein gene in Japanese familial Alzheimer's disease .
1678058
1991
×
Entrez Id:
351
Gene Symbol:
APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).
12192006
2002
×
Entrez Id:
351
Gene Symbol:
APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Leptin reduces the accumulation of Abeta and phosphorylated tau induced by 27-hydroxycholesterol in rabbit organotypic slices.
20157255
2010
×
Entrez Id:
351
Gene Symbol:
APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Inhibition of human high-affinity copper importer Ctr1 orthologous in the nervous system of Drosophila ameliorates Aβ42-induced Alzheimer's disease-like symptoms.
23827522
2013
×
Entrez Id:
351
Gene Symbol:
APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Increasing the predictive accuracy of amyloid-β blood-borne biomarkers in Alzheimer's disease.
21157020
2011
×
Entrez Id:
351
Gene Symbol:
APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Impaired modulation of GABAergic transmission by muscarinic receptors in a mouse transgenic model of Alzheimer's disease.
12746438
2003
×
Entrez Id:
351
Gene Symbol:
APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Identification of the key molecules involved in chronic copper exposure-aggravated memory impairment in transgenic mice of Alzheimer's disease using proteomic analysis.
25352456
2015
×
Entrez Id:
351
Gene Symbol:
APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Hypothesis for a common basis for neuroprotection in glaucoma and Alzheimer's disease: anti-apoptosis by alpha-2-adrenergic receptor activation.
12852432
2003
×
Entrez Id:
351
Gene Symbol:
APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
High performance plasma amyloid-β biomarkers for Alzheimer's disease.
29420472
2018
×
Entrez Id:
351
Gene Symbol:
APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Here, we generated a double homozygous knock-in mouse model that incorporates the Swedish familial Alzheimer's disease mutations and converts mouse Abeta to the human sequence in amyloid precursor protein and had the P264L familial Alzheimer's disease mutation in presenilin-1.
16651627
2006
×
Entrez Id:
351
Gene Symbol:
APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Exposure to metal ions regulates mRNA levels of APP and BACE1 in PC12 cells: blockage by curcumin.
18583042
2008
×
Entrez Id:
351
Gene Symbol:
APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Early effects of aluminum chloride on beta-secretase mRNA expression in a neuronal model of beta-amyloid toxicity.
20111991
2010